Abstract Neuroendocrine prostate cancer is an aggressive variant of prostate cancer that may arise de novo or develop from pre-existing prostate adenocarcinoma as a mechanism of treatment resistance. The combined loss of tumor suppressors RB1. TP53. and PTEN are frequent in NEPC but also present in a subset of prostate adenocarcinomas. https://herbsdailyes.shop/product-category/b12-vitamins-methylcobalamine/